It can mean many things, depending on the issue concerned. Examples: USC = United States Currency (currency American or from us: UU) USC = United States Code (code of us: UU:) USC = University of South Carolina (US) USC = Universidad Santiago de Cali (Colombia) USC = University of Santiago of Chile USC = University of Santiago de Compostela (Spain) USC = Socialist Union of Catalonia (Spain) USC = Social unity Christian (Costa Rica)